Two inscriptions, both of which refer to Bishop Angelo Cesi of Todi, record that the most important families of Narni built this church and the adjoining Benedictine nunnery:
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✴one, dated 1602, is in the vaults of the presbytery); and
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✴the other, dated 1604 , is on the water stoup.
The convent seems to have been reserved, at least initially, for noble women. It was suppressed in the 19th century, when the few remaining nuns moved to Santa Restituta.
An inscription [on a marble plaque that is now outside the church] records that the otherwise unknown Aurelio Amigazzi di Bergamo commissioned the decoration of the church in 1606 in return for Masses to be said for his soul.
Martyrdom of St Margaret of Antioch (ca. 1606)
These important frescoes on the walls depict four scenes of the martyrdom of St Margaret of Antioch (died 303). They are variously attributed to Federico Zuccari or to Antonio Circignani, il Pomarancio.
Scenes from the Life of King David (17th century)
These frescoes in the choir are attributed to Girolamo Troppa.
